Fibroblasts, myofibroblasts, and wound contraction

clinical case reconstructed by Guido Majno (1975) from the Hippocratic records describes a wrestler who visits the iatreion (out-patient clinic) to be treated for a shoulder dislocation. With less invasive procedures no longer working to tighten the dislocation, the clinic adopts the drastic measure of inducing wound contraction by poking a hot needle through the skin of the armpit, and "in thi...

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Fibroblasts and myofibroblasts in wound healing

(Myo)fibroblasts are key players for maintaining skin homeostasis and for orchestrating physiological tissue repair. (Myo)fibroblasts are embedded in a sophisticated extracellular matrix (ECM) that they secrete, and a complex and interactive dialogue exists between (myo)fibroblasts and their microenvironment. In addition to the secretion of the ECM, (myo)fibroblasts, by secreting matrix metallo...

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Mini-Review on the Cellular Mechanisms of Disease Fibroblasts, Myofibroblasts, and Wound Contraction

clinical case reconstructed by Guido Majno (1975) from the Hippocratic records describes a wrestler who visits the iatreion (out-patient clinic) to be treated for a shoulder dislocation. With less invasive procedures no longer working to tighten the dislocation, the clinic adopts the drastic measure of inducing wound contraction by poking a hot needle through the skin of the armpit, and "in thi...

متن کامل

Mini-Review on the Cellular Mechanisms of Disease Fibroblasts, Myofibroblasts, and Wound Contraction

clinical case reconstructed by Guido Majno (1975) from the Hippocratic records describes a wrestler who visits the iatreion (out-patient clinic) to be treated for a shoulder dislocation. With less invasive procedures no longer working to tighten the dislocation, the clinic adopts the drastic measure of inducing wound contraction by poking a hot needle through the skin of the armpit, and "in thi...

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Vanadate and the absence of myofibroblasts in wound contraction.

HYPOTHESIS Fibroblasts, not myofibroblasts, are responsible for wound contraction. Only myofibroblasts express a smooth muscle actin for which vanadate blocks its expression. Wound contraction in vanadate-treated rats will proceed normally in the absence of myofibroblasts. DESIGN Laboratory study using rats. METHODS Wound healing in rats receiving vanadate parenterally, an inhibitor of tyro...

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Fibroblasts, myofibroblasts, and wound contraction

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